The Core of Brightum

Brightum blends 3 unique algae (seaweed) extracts enriched with marine poly/oligosaccharides (carbohydrates). They are rich sources of hydrolytic oligosaccharides, highly sulfated oligo-fucoidans and high molecular weight (HMW) fucoidan complexes.

Brightum blends 3 unique algae (seaweed) extracts especially enriched with marine poly/oligosaccharides (carbohydrates).

Thanks to the specially sourced seaweed and the state-of-the-art extraction and refinement processes, 3 potent marine extracts are stably retrieved.
Atlantic Ocean Gigartina Extract
Rich in hydrolytic oligo-saccharides.
Iroise Sea
Laminaria (Kelp) Extract
Rich in highly sulfated oligo-fucoidans.
Atlantic Ocean Ascophyllum Extract
Rich in HMW fucoidan complexes.

1. Gigartina Extract

The unique Gigartina extract is enriched with marine hydrolytic oligosaccharides.

A
Raw extract is prepared from sustainably managed Gigartina from the Atlantic Ocean.
B
Hydrolytic enzymes from a marine gamma- proteobacteria is purified.
C
In a novel fermentation process, purified enzymes hydrolyze raw extract into an exclusive blend enriched with oligosaccharides.
Hydrolytic oligosaccharides

2. Ascophyllum Nodosum Extract

The Ascophyllum Nodosum extract is enriched with marine fucoidan complexes.

A
Within the Ascophyllum Nodosum from the Atlantic Ocean, the fucoidans naturally complexed with other marine molecules, creating big complexed molecules.
B
A unique process generates fucoidan extract enriched with bigger molecules of fucoidans complexed with various other marine molecules.
Fucoidan complexes

3. Laminaria Extract

The Laminaria extract is enriched with highly sulfated oligo-fucoidans.

A
Fucoidans extracted from Laminaria of the Iroise Sea are rich in bioactive sulfate content.
B
A unique fermentation process generates small molecules of highly sulfated fucoidans. These are ultimate oligo - fucoidans.
Highly sulfated
oligo-fucoidans
How it works

How Brightum works

Brightum harnesses the power of 3 unique marine extracts to reprogram, reform and renew skin. It supports every single node essential for skin vitality, helping it revive, rejuvenate and revitalize.

Oligosaccharides

Renew

Hydrolytic Oligosaccharides from Gigartina seaweed: boost skin renewal to perfect skin;

Fucoidan Complexes

Even

HMW Fucoidan Complexes from Ascophyllum seaweed: enhance skin clarity & improve dullness;

Oligo-fucoidans

Fill

Highly Sulfated Oligo-fucoidans from Laminaria: soften the look of fine lines and wrinkles.

In-vitro studies suggest that Brightum enhances skin fitness by promoting multiple cellular and molecular functions of several skin-related cells. Significant improvement of hydration, microreliefs, dullness, pigmentation, wrinkle and fine lines was observed in clinical studies.
Know more
Improve skin hydration & reinforce skin defense
+
Improve skin complexion; soften fine lines & wrinkles
+
Revitalize skin
+
Even skin tone & revive dullness
+
The Facial Treatment Mask

Multi-action rejuvenating facial treatment infused with Brightum Technology

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The Facial Treatment Mask

Multi-action rejuvenating facial treatment infused with Brightum Technology

Start with revitalizing skin epidermal cells and fibroblasts

A clinical study with 20 volunteers aged from 35 to 65 was conducted to evaluate efficacy of Brightum* on human skin renewal. The pigmentation model (DHA) is used to quantify the skin renewal capacity. Pigmentation is eliminated faster if the cell renewal is activated. Cream containing pseudo substance or Brightum was applied twice a day for 12 days.


The results indicate that Brightum* improved skin renewal, more than
doubled in just 4 days (p˂0.001).

Brightum clinically improves human skin renewal

Human dermal fibroblasts were treated with Brightum** as 0.15%
and 1.5%. The same fibroblasts treated with vehicle only were served as negative control. The cell number was quantified for each treatment
after 48-hours.


The results indicate that Brightum** supports and enhances the growth
of dermal fibroblasts.

Brightum enhances skin fibroblast proliferation

Improve skin’s hydration and barrier function

A clinical study was conducted with 20 volunteers aging from 35 to 65 to evaluate the efficacy of Brightum* in improving skin hydration. Cream containing pseudo substance or Brightum was applied twice a day for 28 days. At the beginning and end of the study, skin hydration was assessed
by corneometer.


The results indicate that 95% of volunteers observed significant
improvement. The average hydration improvement is as high as
16.5%. The 8.8% difference between Brightum* and the control
indicates a well-improved skin barrier function. *p˂0.05, **p˂0.01,
***p˂0.001

Brightum clinically improves skin hydration

Reinforce epidermis structure

Keratinocytes are the most abundant cell types within epidermis which is the outermost layer of the skin. To evaluate the genetic impact of Brightum* on human keratinocytes, total RNA was extracted from human keratinocytes treated with/without Brightum. Quantitative real-time PCR (qRT-PCR) was performed to profile change of gene expression of various skin biology – related genes.

Brightum differentially regulates gene expression of various factors critical to skin biology

 

Cellular Factor

Function

Gene Impact

Skin Integrity & Architecture

Loricrin

Major protein component that constitutes protective barrier of skin.

+519%

Corneodesmosin

Critical cohesion proteins of skin barrier stratum corneum

+214%

Type I keratinocyte transglutaminase

A critical enzyme catalyzes protein-protein cross-links to maintain skin’s architecture.

+982%

Caspase 14

An enzyme critical for skin’s barrier function.

+ 3366%

Keratin 10

A cellular marker for skin differentiation.

+1801%

Innate Immunity

Beta-defensin 2

A skin antimicrobial peptide

+2255%

Inflammation

Interleukin 8

A proinflammatory mediator within skins.

-169%



The results reveal that Brightum* positively impacts gene expression of
many cellular factors critical for epidermis integrity and skin’s defense
machineries such as cornification, desquamation and innate immunity.
These data suggest a unique role of Brightum in improving skin’s self-
defense capacity, building a strong and healthier skin.

Build a healthier, smoother and softer skin

Microrelief is defined as cutaneous microstructure resembling irregular furrows on the skin surface. Microrelief pattern on skin has been widely used to evaluate skin health and aging. To evaluate the effect of
Brightum* on skin microrelief, a clinical study of 20 volunteers aged from
35 to 65 was conducted. Cream containing with/without Brightum was applied twice a day for 28 days. At the beginning and end of this study,
skin texture was evaluated by the profilometry.


The results indicate that Brightum* decreases the skin’s microrelief,
-6.3% on average and up to -42.9%. These data suggest the role of
Brightum in smoothing and softening the skin texture.

Brightum clinically decrease microrelief

Enhance skin clarity and luminosity by targeting pigment cells

Irregular accumulating of melanin within the epidermis can cause uneven tones and skin pigmentation. Melanin is produced by melanocyte, a pigment cell within epidermis. Within melanocytes, an enzyme called tyrosinase utilizes tyrosine to generate pigment melanin. To evaluate the effect of Brightum*** on melanin production, an in-vitro assay was generated to mimic the process which tyrosinase utilizes tyrosine to generate melanin, plus Brightum could be added. The results were obtained by quantifying melanin levels.


The results indicate that Brightum*** significantly reduces melanin
production. These data also suggest the potential role of Brightum in
mediating melanocyte to produce less pigment melanin.

Brightum significantly reduce melanin production

To further evaluate the effect of Brightum*** on human skin tones, a
clinical study of 24 volunteers were conducted. Cream containing with/without Brightum was applied twice a day for 28 days. At the beginning and end of this study, the color of skin was measured by a chromameter. The results were analyzed by using skin color topology.
Data was summarized by using typology angles generated from
volunteers.


The results indicate that Brightum*** significantly increases skin clarity
and decreases skin pigmentation.

Brightum enhances skin fibroblast proliferation

Reprogram dermal fibroblasts to enhance collagen production

Collagen loss can cause fine lines and wrinkles. The loss of collagen can also reduce skin elasticity. To evaluate the effect of Brightum** on collagen production, in-vitro studies were performed. Human dermal fibroblasts from healthy donners were cultured with/without Brightum for 48 hours. At the end of the study, collagen synthesis was evaluated.


The results indicate that Brightum** enhances type I collagen synthesis of
human dermal fibroblasts.

Brightum stimulates Type I collagen production

To further evaluate the effect of Brightum** in a clinical setting, 42 volunteers with wrinkles in the crow’s feet area were recruited to use cream with/without Brightum twice a day and total for 28 days. At the beginning and the end of the study, the depth of crow’s feet wrinkles was evaluated by skin profilometry.


The results indicate that Brightum** decreases the wrinkle depth of
human skin, as high as 9.1% average in comparison with the control. **p˂0.01

Brightum clinically improves winkle depth

Start with revitalizing
skin epidermal cells and
fibroblasts
Improve skin’s hydration
and barrier function
Reinforce epidermis
structure
Build a healthier,
smoother and
softer skin
Enhance skin clarity and luminosity by targeting pigment cells
Reprogram dermal fibroblasts to enhance collagen production
© 2020 NEOCYAN LLC. – ALL RIGHTS RESERVED

All the products described on this website are intended to meet the FDA's definition of a cosmetic product, an article applied to the human body to cleanse, beautify, promote attractiveness, and alter appearances. These products are not intended to be drug products that diagnose, treat, cure, or prevent any disease or condition. These products have not been approved by the FDA and the statements on these pages have not been evaluated by the FDA.

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